HORDB

ID: hor000808
Uniprot ID: A0NDK8
Protein name: Corazonin
Gene name: CRZ
Organism: Anopheles gambiae (African malaria mosquito)
Family: Corazonin family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: gambiae species complex, Pyretophorus, Cellia (subgenus), Anopheles (genus), Anophelinae (subfamily), Culicidae (family), Culicoidea (superfamily), Culicomorpha (infraorder), Nematocera (suborder), Diptera (order), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005184 neuropeptide hormone activity; GO:0071858 corazonin receptor binding
GO BP: GO:0007218 neuropeptide signaling pathway; GO:0045823 positive regulation of heart contraction
GO CC: GO:0005576 extracellular region

Sequence: QTFQYSRGWTN
Length: 11(21-31)
Propeptide: MLHTRTIALLLVGLVVLVNAQTFQYSRGWTNGKRSPLSSSSSSPSSSAAMEPLTANQLLASALSSGGLNSLKPSEKALLRRFLRNPCDLRVASLLAAAHPTKELFPLAGNSFDSAESAGAAFVLPPFLMDPDESNGGIGGSNLANGRSMEDELRFKRGTATGFSDHRQKIA
Signal peptide: MLHTRTIALLLVGLVVLVNA
Modification: T1 Pyrrolidone carboxylic acid;T11 Asparagine amide
Glycosylation: NA
Mutagenesis: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor000808_AF2.pdb

hor000808_ESM.pdb

Mass:	156601	Formula:	C62H86N18O19
Absent amino acids:	ACDEHIKLMPV	Common amino acids:	QT
pI:	9.35	Basic residues:	1
Polar residues:	6	Hydrophobic residues:	2
Hydrophobicity:	-154.55	Boman Index:	-3507
Half-Life:	0.8 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	0
Instability Index:	713.64	Extinction Coefficient cystines:	6990
Absorbance 280nm:	699